Importin β Interacts with the Endoplasmic Reticulum-associated Degradation Machinery and Promotes Ubiquitination and Degradation of Mutant α1-Antitrypsin

The mechanism by which misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytosol for proteasomal degradation is still poorly understood. Here, we show that importin β, a well established nucleocytoplasmic transport protein, interacts with components of the retrotransl...

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Главные авторы: Zhong, Yongwang, Wang, Yang, Yang, Hui, Ballar, Petek, Lee, Jin-gu, Ye, Yihong, Monteiro, Mervyn J., Fang, Shengyun
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Protein Synthesis and Degradation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190800/
https://ncbi.nlm.nih.gov/pubmed/21832065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272906
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