Multiple Glycogen-binding Sites in Eukaryotic Glycogen Synthase Are Required for High Catalytic Efficiency toward Glycogen

Glycogen synthase is a rate-limiting enzyme in the biosynthesis of glycogen and has an essential role in glucose homeostasis. The three-dimensional structures of yeast glycogen synthase (Gsy2p) complexed with maltooctaose identified four conserved maltodextrin-binding sites distributed across the su...

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Bibliographische Detailangaben
Hauptverfasser: Baskaran, Sulochanadevi, Chikwana, Vimbai M., Contreras, Christopher J., Davis, Keri D., Wilson, Wayne A., DePaoli-Roach, Anna A., Roach, Peter J., Hurley, Thomas D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190777/
https://ncbi.nlm.nih.gov/pubmed/21835915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264531
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