Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site

Glutamate dehydrogenase (GDH) catalyzes the oxidative deamination of l-glutamate and, in animals, is extensively regulated by a number of metabolites. Gain of function mutations in GDH that abrogate GTP inhibition cause the hyperinsulinism/hyperammonemia syndrome (HHS), resulting in increased pancre...

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Main Authors: Li, Changhong, Li, Ming, Chen, Pan, Narayan, Srinivas, Matschinsky, Franz M., Bennett, Michael J., Stanley, Charles A., Smith, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190766/
https://ncbi.nlm.nih.gov/pubmed/21813650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.268599
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