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Proton-sensing Ca(2+) Binding Domains Regulate the Cardiac Na(+)/Ca(2+) Exchanger
The cardiac Na(+)/Ca(2+) exchanger (NCX) regulates cellular [Ca(2+)](i) and plays a central role in health and disease, but its molecular regulation is poorly understood. Here we report on how protons affect this electrogenic transporter by modulating two critically important NCX C(2) regulatory dom...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3190689/ https://ncbi.nlm.nih.gov/pubmed/21680748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214106 |
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