Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa

Neutrophils enter the peripheral blood from the bone marrow and die after a short time. Molecular analysis of spontaneous neutrophil apoptosis is difficult as these cells die rapidly and cannot be easily manipulated. We use conditional Hoxb8 expression to generate mouse neutrophils and test the regu...

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Detalhes bibliográficos
Main Authors: Kirschnek, S, Vier, J, Gautam, S, Frankenberg, T, Rangelova, S, Eitz-Ferrer, P, Grespi, F, Ottina, E, Villunger, A, Häcker, H, Häcker, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190116/
https://ncbi.nlm.nih.gov/pubmed/21660046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.69
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