Induction of Noxa-Mediated Apoptosis by Modified Vaccinia Virus Ankara Depends on Viral Recognition by Cytosolic Helicases, Leading to IRF-3/IFN-β-Dependent Induction of Pro-Apoptotic Noxa

Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure. An MVA mutant lacking F1L (MVAΔF1L) induces a...

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Detaylı Bibliyografya
Asıl Yazarlar: Eitz Ferrer, Pedro, Potthoff, Stephanie, Kirschnek, Susanne, Gasteiger, Georg, Kastenmüller, Wolfgang, Ludwig, Holger, Paschen, Stefan A., Villunger, Andreas, Sutter, Gerd, Drexler, Ingo, Häcker, Georg
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116819/
https://ncbi.nlm.nih.gov/pubmed/21698224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002083
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