Induction of Noxa-Mediated Apoptosis by Modified Vaccinia Virus Ankara Depends on Viral Recognition by Cytosolic Helicases, Leading to IRF-3/IFN-β-Dependent Induction of Pro-Apoptotic Noxa

Viral infection is a stimulus for apoptosis, and in order to sustain viral replication many viruses are known to carry genes encoding apoptosis inhibitors. F1L, encoded by the orthopoxvirus modified vaccinia virus Ankara (MVA) has a Bcl-2-like structure. An MVA mutant lacking F1L (MVAΔF1L) induces a...

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Main Authors: Eitz Ferrer, Pedro, Potthoff, Stephanie, Kirschnek, Susanne, Gasteiger, Georg, Kastenmüller, Wolfgang, Ludwig, Holger, Paschen, Stefan A., Villunger, Andreas, Sutter, Gerd, Drexler, Ingo, Häcker, Georg
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116819/
https://ncbi.nlm.nih.gov/pubmed/21698224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002083
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