Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa

Neutrophils enter the peripheral blood from the bone marrow and die after a short time. Molecular analysis of spontaneous neutrophil apoptosis is difficult as these cells die rapidly and cannot be easily manipulated. We use conditional Hoxb8 expression to generate mouse neutrophils and test the regu...

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Autors principals: Kirschnek, S, Vier, J, Gautam, S, Frankenberg, T, Rangelova, S, Eitz-Ferrer, P, Grespi, F, Ottina, E, Villunger, A, Häcker, H, Häcker, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190116/
https://ncbi.nlm.nih.gov/pubmed/21660046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.69
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