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Allosteric modulation of Ca(2+) channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)β subunits

N-type and P/Q-type Ca(2+) channels are inhibited by neurotransmitters acting through G protein-coupled receptors in a membrane-delimited pathway involving Gβγ subunits. Inhibition is caused by a shift from an easily activated “willing” (W) state to a more-difficult-to-activate “reluctant” (R) state...

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Detalhes bibliográficos
Main Authors: Herlitze, Stefan, Zhong, Huijun, Scheuer, Todd, Catterall, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31897/
https://ncbi.nlm.nih.gov/pubmed/11296298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051628998
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