Adenovirus 5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part A: Safety and Immunogenicity in Seronegative Adults

BACKGROUND: Models of immunity to malaria indicate the importance of CD8+ T cell responses for targeting intrahepatic stages and antibodies for targeting sporozoite and blood stages. We designed a multistage adenovirus 5 (Ad5)-vectored Plasmodium falciparum malaria vaccine, aiming to induce both typ...

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主要な著者: Sedegah, Martha, Tamminga, Cindy, McGrath, Shannon, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J., Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Manohar, Nalini, Richie, Nancy O., Wood, Chloe, Long, Carole A., Regis, David, Williams, Francis T., Shi, Meng, Chuang, Ilin, Spring, Michele, Epstein, Judith E., Mendoza-Silveiras, Jose, Limbach, Keith, Patterson, Noelle B., Bruder, Joseph T., Doolan, Denise L., King, C. Richter, Soisson, Lorraine, Diggs, Carter, Carucci, Daniel, Dutta, Sheetij, Hollingdale, Michael R., Ockenhouse, Christian F., Richie, Thomas L.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2011
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189181/
https://ncbi.nlm.nih.gov/pubmed/22003383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024586
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