Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

We have previously shown that a DNA-prime followed by an adenovirus-5 boost vaccine containing CSP and AMA1 (DNA/Ad) successfully protected 4 of 15 subjects to controlled human malaria infection (CHMI). However, the adenovirus-5 vaccine alone (AdCA) failed to induce protection despite eliciting cell...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Vaccin Immunother
Hauptverfasser: Sedegah, Martha, Hollingdale, Michael R, Farooq, Fouzia, Ganeshan, Harini, Belmonte, Maria, Huang, Jun, Abot, Esteban, Limbach, Keith, Chuang, Ilin, Tamminga, Cindy, Epstein, Judith E, Villasante, Eileen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685686/
https://ncbi.nlm.nih.gov/pubmed/26292027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2015.1019186
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