Interleukin 37 expression protects mice from colitis

IL-37, a newly described member of the IL-1 family, functions as a fundamental inhibitor of innate inflammation and immunity. In the present study, we examined a role for IL-37 during experimental colitis. A transgenic mouse strain was generated to express human IL-37 (hIL-37tg), and these mice were...

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Main Authors: McNamee, Eóin N., Masterson, Joanne C., Jedlicka, Paul, McManus, Martine, Grenz, Almut, Collins, Colm B., Nold, Marcel F., Nold-Petry, Claudia, Bufler, Philip, Dinarello, Charles A., Rivera-Nieves, Jesús
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2011
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189085/
https://ncbi.nlm.nih.gov/pubmed/21873195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111982108
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