SPA0355, a thiourea analogue, inhibits inflammatory responses and joint destruction in fibroblast-like synoviocytes and mice with collagen-induced arthritis

BACKGROUND AND PURPOSE: NF-κB has been implicated as a therapeutic target for the treatment of rheumatoid arthritis. We previously synthesized a thiourea analogue, SPA0355, which suppressed NF-κB activity. Here we have assessed the anti-inflammatory and anti-arthritic effects of SPA0355. EXPERIMENTA...

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Detalhes bibliográficos
Main Authors: Lee, YR, Hwang, JK, Lee, HS, Cheon, YJ, Ryu, JH, Lee, SI, Kwak, HB, Lee, SM, Kim, JS, Park, JW, Jeon, R, Park, BH
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Themed Section: Immunology & Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188917/
https://ncbi.nlm.nih.gov/pubmed/21501144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01441.x
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