2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52) – a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo

BACKGROUND AND PURPOSE: 5-Lipoxygenase (5-LO) is the key enzyme in the biosynthesis of pro-inflammatory leukotrienes (LTs) representing a potential target for pharmacological intervention with inflammation and allergic disorders. Although many LT synthesis inhibitors are effective in simple in vitro...

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Autors principals: Greiner, C, Hörnig, C, Rossi, A, Pergola, C, Zettl, H, Schubert-Zsilavecz, M, Steinhilber, D, Sautebin, L, Werz, O
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2011
Matèries:
Themed Section: Immunology & Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188909/
https://ncbi.nlm.nih.gov/pubmed/21506958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01451.x
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