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Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

BACKGROUND AND PURPOSE: Fangchinoline is a novel anti-tumour agent with little known of its cellular and molecular mechanisms of action. Here we have investigated the mode of cell death induced by fangchinoline and its underlying mechanism in two human hepatocellular carcinoma cell lines, HepG2 and...

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Autori principali: Wang, Ning, Pan, Weidong, Zhu, Meifen, Zhang, Maosheng, Hao, Xiaojian, Liang, Guangyi, Feng, Yibin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188903/
https://ncbi.nlm.nih.gov/pubmed/21418191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01349.x
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