Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the malignancy derived from normal hepatocytes with increasing incidence and extremely poor prognosis worldwide. The only approved first‐line systematic treatment agent for HCC, sorafenib, is capable to effectively improve advanced HCC patients’ survival. However, i...

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Bibliografiske detaljer
Udgivet i:Cancer Med
Main Authors: Dai, Jimin, Huang, Qichao, Niu, Kunwei, Wang, Bo, Li, Yijie, Dai, Chen, Chen, Zhinan, Tao, Kaishan, Dai, Jingyao
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247041/
https://ncbi.nlm.nih.gov/pubmed/30311444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1826
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