Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells

BACKGROUND AND PURPOSE: Fangchinoline is a novel anti-tumour agent with little known of its cellular and molecular mechanisms of action. Here we have investigated the mode of cell death induced by fangchinoline and its underlying mechanism in two human hepatocellular carcinoma cell lines, HepG2 and...

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Hlavní autoři: Wang, Ning, Pan, Weidong, Zhu, Meifen, Zhang, Maosheng, Hao, Xiaojian, Liang, Guangyi, Feng, Yibin
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2011
Témata:
Themed Section: Molecular & Cellular Mechanisms
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188903/
https://ncbi.nlm.nih.gov/pubmed/21418191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01349.x
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