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Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

Ciliary Neurotrophic Factor (CNTF) was first characterized as a trophic factor for motor neurons in the ciliary ganglion and spinal cord, leading to its evaluation in humans suffering from motor neuron disease. In these trials, CNTF caused unexpected and substantial weight loss, raising concerns tha...

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Bibliografski detalji
Glavni autori: Lambert, P. D., Anderson, K. D., Sleeman, M. W., Wong, V., Tan, J., Hijarunguru, A., Corcoran, T. L., Murray, J. D., Thabet, K. E., Yancopoulos, G. D., Wiegand, S. J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2001
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC31889/
https://ncbi.nlm.nih.gov/pubmed/11259650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061034298
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