Deptor Knockdown Enhances mTOR Activity and Protein Synthesis in Myocytes and Ameliorates Disuse Muscle Atrophy

Deptor is an mTOR binding protein that affects cell metabolism. We hypothesized that knockdown (KD) of Deptor in C2C12 myocytes will increase protein synthesis via stimulating mTOR-S6K1 signaling. Deptor KD was achieved using lentiviral particles containing short hairpin (sh)RNA targeting the mouse...

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Hlavní autoři: Kazi, Abid A, Hong-Brown, Ly, Lang, Susan M, Lang, Charles H
Médium: Artigo
Jazyk:Inglês
Vydáno: ScholarOne 2011
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188866/
https://ncbi.nlm.nih.gov/pubmed/21607293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00070
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