A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1

Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that promote insulin action. Serine phosphorylation uncouples IRS-1 from the insulin receptor, thereby inhibiting its tyrosine phosphorylation and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ozes, Osman Nidai, Akca, Hakan, Mayo, Lindsey D., Gustin, Jason A., Maehama, Tomohiko, Dixon, Jack E., Donner, David B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC31887/
https://ncbi.nlm.nih.gov/pubmed/11287630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051042298
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge