Differentiation of Chronic Lymphocytic Leukemia B Cells into Immunoglobulin Secreting Cells Decreases LEF-1 Expression

Lymphocyte enhancer binding factor 1 (LEF-1) plays a crucial role in B lineage development and is only expressed in B cell precursors as B cell differentiation into mature B and plasma cells silences its expression. Chronic lymphocytic leukemia (CLL) cells aberrantly express LEF-1 and its expression...

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Bibliographic Details
Main Authors: Gutierrez, Albert, Arendt, Bonnie K., Tschumper, Renee C., Kay, Neil E., Zent, Clive S., Jelinek, Diane F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188588/
https://ncbi.nlm.nih.gov/pubmed/21998751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026056
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