Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients

Survival of patients with B cell chronic lymphocytic leukemia (B-CLL) can be predicted by analysis of mutations in the immunoglobulin heavy chain variable gene (IGHV). Patients without mutations (unmutated [UM]) are at greater risk for disease progression and death than patients with mutations (M)....

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Detalhes bibliográficos
Main Authors: Tschumper, Renee C., Geyer, Susan M., Campbell, Megan E., Kay, Neil E., Shanafelt, Tait D., Zent, Clive S., Nowakowski, Grzegorz S., Call, Timothy G., Dewald, Gordon W., Jelinek, Diane F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117767/
https://ncbi.nlm.nih.gov/pubmed/18064298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32625
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