LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis

The canonical Wnt signaling pathway is pathogenic in a variety of cancers. We previously identified aberrant expression of the Wnt pathway transcription factor and target gene lymphoid enhancer binding factor-1 (LEF1) in chronic lymphocytic leukemia (CLL). This suggested that the Wnt signaling pathw...

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Autors principals: Gutierrez, Albert, Tschumper, Renee C., Wu, Xiaosheng, Shanafelt, Tait D., Eckel-Passow, Jeanette, Huddleston, Paul M., Slager, Susan L., Kay, Neil E., Jelinek, Diane F.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974605/
https://ncbi.nlm.nih.gov/pubmed/20595513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-269878
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