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Hyperforin Inhibits Akt1 Kinase Activity and Promotes Caspase-Mediated Apoptosis Involving Bad and Noxa Activation in Human Myeloid Tumor Cells

BACKGROUND: The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells abnormally proliferate and escape apoptosis. Herein, the effects and mechanisms of purified HF on AML cell dysfunction...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Merhi, Faten, Tang, Ruoping, Piedfer, Marion, Mathieu, Julie, Bombarda, Isabelle, Zaher, Murhaf, Kolb, Jean-Pierre, Billard, Christian, Bauvois, Brigitte
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188562/
https://ncbi.nlm.nih.gov/pubmed/21998731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025963
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