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The CNGRC-GG-(D)(KLAKLAK)(2) peptide induces a caspase-independent, Ca(2+)-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13
The CD13 antigen's binding site for the Asn-Gly-Arg (NGR) motif enables NGR-containing chemotherapeutic drugs to be delivered to CD13-positive tumours. Human CD13-positive acute myeloid leukemia (AML) cells proliferate abnormally and escape death. Here, we show that the CNGRC-GG-(D)(KLAKLAK)(2)...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4991394/ https://ncbi.nlm.nih.gov/pubmed/26655501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6523 |
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