Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells

Secreted matrix metalloproteinases (MMP)-2 and MMP-9 and membrane-anchored aminopeptidase-N/CD13 are abnormally expressed in human acute myeloid leukaemia (AML). We previously showed that CD13 ligation by anti-CD13 monoclonal antibodies can induce apoptosis in AML cells. Here, we assessed ADAM17 exp...

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Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Bouchet, Sandrine, Tang, Ruoping, Fava, Fanny, Legrand, Ollivier, Bauvois, Brigitte
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226678/
https://ncbi.nlm.nih.gov/pubmed/25246708
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