Hyperforin Inhibits Akt1 Kinase Activity and Promotes Caspase-Mediated Apoptosis Involving Bad and Noxa Activation in Human Myeloid Tumor Cells

BACKGROUND: The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells abnormally proliferate and escape apoptosis. Herein, the effects and mechanisms of purified HF on AML cell dysfunction...

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Detalhes bibliográficos
Main Authors: Merhi, Faten, Tang, Ruoping, Piedfer, Marion, Mathieu, Julie, Bombarda, Isabelle, Zaher, Murhaf, Kolb, Jean-Pierre, Billard, Christian, Bauvois, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188562/
https://ncbi.nlm.nih.gov/pubmed/21998731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025963
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