Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila

Over-expression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast, Caenorhabditis elegans and Drosophila melanogaster(1-3). Studies of gene effects on ageing are vulnerable to confounding effects of genetic background(4). We re-examined the r...

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Main Authors: Burnett, Camilla, Valentini, Sara, Cabreiro, Filipe, Goss, Martin, Somogyvári, Milán, Piper, Matthew D., Hoddinott, Matthew, Sutphin, George L., Leko, Vid, McElwee, Joshua J., Vazquez, Rafael, Orfila, Anne-Marie, Ackerman, Daniel, Au, Catherine, Vinti, Giovanna, Riesen, Michèle, Howard, Ken, Neri, Christian, Bedalov, Antonio, Kaeberlein, Matt, Söti, Csaba, Partridge, Linda, Gems, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188402/
https://ncbi.nlm.nih.gov/pubmed/21938067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10296
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