Activation of Promoter Activity of the Catalytic Subunit of γ-Glutamylcysteine Ligase (GCL) in Brain Endothelial Cells by Insulin Requires Antioxidant Response Element 4 and Altered Glycemic Status: Implication for GCL expression and GSH synthesis

Our recent finding that insulin increased the expression of glutamate cysteine ligase catalytic subunit (GCLc) and coincident increases in GCL activity and cellular glutathione (GSH) in human brain microvascular endothelial cells (IHECs) suggests a role for insulin in vascular GSH maintenance. Here,...

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Bibliographische Detailangaben
Hauptverfasser: Langston, William, Li, Wei, Harrison, Lynn, Aw, Tak Yee
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188337/
https://ncbi.nlm.nih.gov/pubmed/21871559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.08.004
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