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An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen

Nrf2, a member of the “cap ‘n collar” group of transcription factors, is important for protecting cells against oxidative damage. We investigated its role in the detoxification of acetaminophen [N-acetyl-p-aminophenol (APAP)]-induced hepatotoxicity. When Nrf2 knockout (Nrf2(−/−)) and wild-type mice...

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Détails bibliographiques
Auteurs principaux: Chan, Kaimin, Han, Xiao-Dong, Kan, Yuet Wai
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC31882/
https://ncbi.nlm.nih.gov/pubmed/11287661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081082098
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