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Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine

Bacterial flagellins are potent inducers of innate immune responses in the mouse lung because they bind to TLR5 expressed on the apical surfaces of airway epithelial cells. TLR engagement leads to the initiation of a signaling cascade that results in a pro-inflammatory response with subsequent up-re...

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Detalhes bibliográficos
Main Authors: Skountzou, Ioanna, Martin, Maria del Pilar, Wang, Baozhong, Ye, Ling, Koutsonanos, Dimitrios, Weldon, Will, Jacob, Joshy, Compans, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187848/
https://ncbi.nlm.nih.gov/pubmed/19654062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.07.058
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