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3′UTR-Mediated Gene Silencing of the Mixed Lineage Leukemia (MLL) Gene

Translocations involving the Mixed Lineage Leukemia (MLL) gene generate in-frame fusions of MLL with more than 50 different partner genes (PGs). Common to all MLL translocations is the exchange not only of coding regions, but also of MLL and PG 3′-untranslated regions (3′UTRs). As a result, the MLL-...

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Main Authors: Gomez-Benito, Maria, Loayza-Puch, Fabricio, Oude Vrielink, Joachim, Odero, Maria D., Agami, Reuven
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187771/
https://ncbi.nlm.nih.gov/pubmed/21998658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025449
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