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3′UTR-Mediated Gene Silencing of the Mixed Lineage Leukemia (MLL) Gene

Translocations involving the Mixed Lineage Leukemia (MLL) gene generate in-frame fusions of MLL with more than 50 different partner genes (PGs). Common to all MLL translocations is the exchange not only of coding regions, but also of MLL and PG 3′-untranslated regions (3′UTRs). As a result, the MLL-...

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Detalhes bibliográficos
Main Authors: Gomez-Benito, Maria, Loayza-Puch, Fabricio, Oude Vrielink, Joachim, Odero, Maria D., Agami, Reuven
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187771/
https://ncbi.nlm.nih.gov/pubmed/21998658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025449
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