Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy

Autophagy has been shown to facilitate replication or production of hepatitis C virus (HCV); nevertheless, how HCV induces autophagy remains unclear. Here, we demonstrate that HCV nonstructural protein 4B (NS4B) alone can induce autophagy signaling; amino acid residues 1 to 190 of NS4B are sufficien...

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Hlavní autoři: Su, Wen-Chi, Chao, Ti-Chun, Huang, Yih-Leh, Weng, Shih-Che, Jeng, King-Song, Lai, Michael M. C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187495/
https://ncbi.nlm.nih.gov/pubmed/21835792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00173-11
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