Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

Endolysin CD27L causes cell lysis of the pathogen Clostridium difficile, a major cause of nosocomial infection. We report a structural and functional analysis of the catalytic activity of CD27L against C. difficile and other bacterial strains. We show that truncation of the endolysin to the N-termin...

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Hauptverfasser: Mayer, Melinda J., Garefalaki, Vasiliki, Spoerl, Rebecca, Narbad, Arjan, Meijers, Rob
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187396/
https://ncbi.nlm.nih.gov/pubmed/21803993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00439-11
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