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Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range
Endolysin CD27L causes cell lysis of the pathogen Clostridium difficile, a major cause of nosocomial infection. We report a structural and functional analysis of the catalytic activity of CD27L against C. difficile and other bacterial strains. We show that truncation of the endolysin to the N-termin...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3187396/ https://ncbi.nlm.nih.gov/pubmed/21803993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00439-11 |
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