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Checkpoint Kinase 1 Prevents Cell Cycle Exit Linked to Terminal Cell Differentiation

Trophoblast stem (TS) cells proliferate in the presence of fibroblast growth factor 4, but in its absence, they differentiate into polyploid trophoblast giant (TG) cells that remain viable but nonproliferative. Differentiation is coincident with expression of the cyclin-dependent kinase (CDK)-specif...

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Detalles Bibliográficos
Main Authors: Ullah, Zakir, de Renty, Christelle, DePamphilis, Melvin L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187358/
https://ncbi.nlm.nih.gov/pubmed/21791608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05723-11
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