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Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

The transmembrane protein Tim-3 has been shown to negatively regulate T-cell-dependent immune responses and was recently demonstrated to be associated with the phenomenon of immune exhaustion, which can occur as a consequence of chronic viral infection. Unlike other negative regulators of T-cell fun...

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Autors principals: Lee, Judong, Su, Ee Wern, Zhu, Chen, Hainline, Sarah, Phuah, Jiayao, Moroco, Jamie A., Smithgall, Thomas E., Kuchroo, Vijay K., Kane, Lawrence P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187355/
https://ncbi.nlm.nih.gov/pubmed/21807895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05297-11
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