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Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli

The path of substrates in the multidrug efflux pump AcrB of Escherichia coli was examined by using labeling with a lipophilic substrate mimic, Bodipy FL maleimide. Four (out of eight) residues in the vestibule bound the dye, suggesting its role in substrate transport, whereas only one (out of nine)...

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書誌詳細
主要な著者: Husain, Fasahath, Bikhchandani, Mihir, Nikaido, Hiroshi
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187200/
https://ncbi.nlm.nih.gov/pubmed/21856849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.05759-11
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