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Effect of the Hepatitis C Virus Protease Inhibitor Telaprevir on the Pharmacokinetics of Amlodipine and Atorvastatin

Telaprevir is a hepatitis C virus protease inhibitor that is both a substrate and an inhibitor of CYP3A. Amlodipine and atorvastatin are both substrates of CYP3A and are among the drugs most frequently used by patients with hepatitis C. This study was conducted to examine the effect of telaprevir on...

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Autori principali: Lee, Jee Eun, van Heeswijk, Rolf, Alves, Katia, Smith, Frances, Garg, Varun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187007/
https://ncbi.nlm.nih.gov/pubmed/21825288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00653-11
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