Pharmacokinetic Evaluation of the Interaction between Hepatitis C Virus Protease Inhibitor Boceprevir and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Atorvastatin and Pravastatin

Boceprevir is a potent orally administered inhibitor of hepatitis C virus and a strong, reversible inhibitor of CYP3A4, the primary metabolic pathway for many 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Thus, the aim of the present study was to investigate drug-drug interac...

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Détails bibliographiques
Auteurs principaux: Hulskotte, E. G. J., Feng, H.-P., Xuan, F., Gupta, S., van Zutven, M. G. J. A., O'Mara, E., Wagner, J. A., Butterton, J. R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2013
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716144/
https://ncbi.nlm.nih.gov/pubmed/23529734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02347-12
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