Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models

Mitochondrial cytochrome c (cyt. c) release and caspase activation are often impaired in tumors with Bcl-2 overexpression or Bax and Bak-defective status. Direct triggering of cell death downstream of Bax and Bak is an attractive strategy to kill such cancers. Small molecule compounds capable of dir...

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Detalhes bibliográficos
Main Authors: Seervi, M, Joseph, J, Sobhan, P K, Bhavya, B C, Santhoshkumar, T R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186908/
https://ncbi.nlm.nih.gov/pubmed/21900958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.90
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