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Procaspase-3 Activation as an Anti-Cancer Strategy: Structure-Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and its Cellular Co-Localization with Caspase-3

A goal of personalized medicine as applied to oncology is to identify compounds that exploit a defined molecular defect in a cancerous cell. A compound called procaspase-activating compound 1 (PAC-1) was reported that enhances the activity of procaspase-3 in vitro and induces apoptotic death in canc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Peterson, Quinn P., Hsu, Danny C., Goode, David R., Novotny, Chris J., Totten, Ryan K., Hergenrother, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749958/
https://ncbi.nlm.nih.gov/pubmed/19708658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900722z
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