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Chronic Chemoimmunotherapy Achieves Cure of Spontaneous Murine Mammary Tumors via Persistent Blockade of Post-therapy Counter-regulation
Intratumoral delivery of Interleukin-12 (IL-12) and Granulocyte Macrophage Colony-stimulating Factor (GM-CSF) induces local and systemic antitumor CD8+ T-cell activation and tumor kill. The effector response however, is transient and is rapidly countered by CD4+ Foxp3+ T-suppressor cell expansion. T...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3186861/ https://ncbi.nlm.nih.gov/pubmed/21908736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101136 |
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