Protective Role of Transient Pore Openings in Calcium Handling by Cardiac Mitochondria

Long-lasting mitochondrial permeability transition pore (mPTP) openings damage mitochondria, but transient mPTP openings protect against chronic cardiac stress. To probe the mechanism, we subjected isolated cardiac mitochondria to gradual Ca(2+) loading, which, in the absence of BSA, induced long-la...

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Bibliographic Details
Main Authors: Korge, Paavo, Yang, Ling, Yang, Jun-Hai, Wang, Yibin, Qu, Zhilin, Weiss, James N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186421/
https://ncbi.nlm.nih.gov/pubmed/21859717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.239921
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