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Role of the Transmembrane Domain 4/Extracellular Loop 2 Junction of the Human Gonadotropin-releasing Hormone Receptor in Ligand Binding and Receptor Conformational Selection

Recent crystal structures of G protein-coupled receptors (GPCRs) show the remarkable structural diversity of extracellular loop 2 (ECL2), implying its potential role in ligand binding and ligand-induced receptor conformational selectivity. Here we have applied molecular modeling and mutagenesis stud...

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Bibliografske podrobnosti
Main Authors: Forfar, Rachel, Lu, Zhi-Liang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186411/
https://ncbi.nlm.nih.gov/pubmed/21832286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240341
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