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Role of the Transmembrane Domain 4/Extracellular Loop 2 Junction of the Human Gonadotropin-releasing Hormone Receptor in Ligand Binding and Receptor Conformational Selection
Recent crystal structures of G protein-coupled receptors (GPCRs) show the remarkable structural diversity of extracellular loop 2 (ECL2), implying its potential role in ligand binding and ligand-induced receptor conformational selectivity. Here we have applied molecular modeling and mutagenesis stud...
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Format: | Artigo |
Jezik: | Inglês |
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American Society for Biochemistry and Molecular Biology
2011
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Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3186411/ https://ncbi.nlm.nih.gov/pubmed/21832286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240341 |
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