Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome

Reduced gene dosage of ribosomal protein subunits has been implicated in 5q− myelodysplastic syndrome and Diamond Blackfan anemia, but the cellular and pathophysiologic defects associated with these conditions are enigmatic. Using conditional inactivation of the ribosomal protein S6 gene in laborato...

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Hauptverfasser: McGowan, Kelly A., Pang, Wendy W., Bhardwaj, Rashmi, Perez, Marcelina G., Pluvinage, John V., Glader, Bertil E., Malek, Reem, Mendrysa, Susan M., Weissman, Irving L., Park, Christopher Y., Barsh, Gregory S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186336/
https://ncbi.nlm.nih.gov/pubmed/21788341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318584
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