Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome

Reduced gene dosage of ribosomal protein subunits has been implicated in 5q− myelodysplastic syndrome and Diamond Blackfan anemia, but the cellular and pathophysiologic defects associated with these conditions are enigmatic. Using conditional inactivation of the ribosomal protein S6 gene in laborato...

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Detalhes bibliográficos
Main Authors: McGowan, Kelly A., Pang, Wendy W., Bhardwaj, Rashmi, Perez, Marcelina G., Pluvinage, John V., Glader, Bertil E., Malek, Reem, Mendrysa, Susan M., Weissman, Irving L., Park, Christopher Y., Barsh, Gregory S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186336/
https://ncbi.nlm.nih.gov/pubmed/21788341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318584
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