Enhanced Hemeoxygenase Activity in the Rostral Ventrolateral Medulla Mediates Exaggerated Hemin-Evoked Hypotension in the Spontaneously Hypertensive Rat

In anesthetized normotensive rats, activation of brainstem hemeoxygenase (HO) elicits sympathoinhibition and hypotension. Accordingly, we tested the hypothesis that attenuated basal or induced HO activity in the rostral ventrolateral medulla (RVLM) contributes to hypertension in the spontaneously hy...

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Detalhes bibliográficos
Main Authors: Nassar, Noha N., Li, Guichu, Strat, Aurel L., Abdel-Rahman, Abdel A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186288/
https://ncbi.nlm.nih.gov/pubmed/21768222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183368
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