Neuronal Nitric Oxide Synthase–Dependent Elevation in Adiponectin in the Rostral Ventrolateral Medulla Underlies G Protein–Coupled Receptor 18–Mediated Hypotension in Conscious Rats

Direct activation of the endocannabinoid receptor G protein–coupled receptor 18 (GPR18) in the rostral ventrolateral medulla (RVLM) of conscious rats by abnormal cannabidiol (Abn CBD; trans-4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol) elevates local nitric oxide (NO)...

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Detalhes bibliográficos
Main Authors: Penumarti, Anusha, Abdel-Rahman, Abdel A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165025/
https://ncbi.nlm.nih.gov/pubmed/25100751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.216036
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