Integrated Transcriptional and Proteomic Analysis with In Vitro Biochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes

Both T-2 toxin and its metabolites are highly potent mycotoxins that can cause severe human and animal diseases upon exposure. Understanding the toxic mechanism and biotransformation process of T-2 toxin at a cellular level is essential for the development of counter-measures. We investigated the ef...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Jianshe, Jiang, Jun, Zhang, Hongxia, Wang, Junping, Cai, Hua, Li, Cheng, Li, Kangbai, Liu, Jing, Guo, Xuejiang, Zou, Guangxun, Wang, Dazhi, Deng, Yiqun, Dai, Jiayin
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186201/
https://ncbi.nlm.nih.gov/pubmed/21685020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.008748
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