Structure-Function Analysis of Porcine Cytochrome P450 3A29 in the Hydroxylation of T-2 Toxin as Revealed by Docking and Mutagenesis Studies

T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Our previous work demonstrated that porcine cytochrome P450 3A29 (CYP3A29) played an important role in the hydroxylation of T-2 toxin. To identify amino acids involved in this metabolic process, T-2...

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Main Authors: Cheng, Guyue, Liu, Changcun, Wang, Xu, Ma, Hongmin, Pan, Yuanhu, Huang, Lingli, Hao, Haihong, Dai, Menghong, Yuan, Zonghui
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153680/
https://ncbi.nlm.nih.gov/pubmed/25184434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106769
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